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Ketamine Assisted Psychotherapy: Unlocking New Paths to Healing By Dr. Courtnay Meletta

Updated: Apr 28

ketamine assisted psychotherapy in los angeles

In the ever-evolving landscape of psychotherapy, Ketamine Assisted Psychotherapy (KAP) stands out as a beacon of innovation and hope. It's a fascinating blend of pharmacology and psychotherapy, one that I have found to be profoundly impactful in my practice. In this blog, I aim to shed light on how Ketamine can catalyze insights and enhance neuroplasticity, particularly through the increase of Brain-Derived Neurotrophic Factor (BDNF) and its effects on the Default Mode Network (DMN).

The Power of Ketamine: Beyond Traditional Therapy

Ketamine, traditionally used as an anesthetic, has emerged as a valuable tool in psychotherapy. Its unique properties offer a different therapeutic experience, one that can lead to significant breakthroughs, especially for those who have found traditional methods less effective. The key to Ketamine's effectiveness lies in its ability to enhance neuroplasticity - the brain's ability to reorganize itself by forming new neural connections.

Boosting Neuroplasticity with BDNF

One of the most intriguing aspects of KAP is its ability to increase levels of BDNF in the brain. BDNF plays a crucial role in neuroplasticity, aiding in the growth and maintenance of brain cells. This influx of BDNF can revitalize neural pathways, making the brain more receptive to new experiences and ways of thinking. It’s akin to tilling the soil of the mind, making it fertile ground for therapeutic insights and deep, lasting change.

Modulating the Default Mode Network

Another significant aspect of Ketamine therapy is its interaction with the Default Mode Network (DMN). The DMN is a network of interacting brain regions associated with self-referential thoughts and mind-wandering. Often, in states of depression or anxiety, the DMN can become overactive, trapping individuals in cycles of negative thinking. Ketamine has been shown to temporarily reduce the activity of the DMN, which can provide a valuable reprieve, allowing for a more objective and fresh perspective on personal challenges.

The Therapeutic Journey with Ketamine

In my practice, KAP  has opened new doors for clients who have felt stuck in their therapeutic journeys. By fostering an environment where the brain's neuroplastic capabilities are enhanced, and the DMN's hold is loosened, clients often find new ways to approach longstanding issues. This process is not just about the biochemical changes in the brain; it's a holistic experience that integrates these changes with supportive psychotherapy, facilitating a transformative journey.


Ketamine Assisted Psychotherapy represents an exciting frontier in mental health treatment. Its ability to foster neuroplasticity and modulate the Default Mode Network presents new hope for individuals seeking deeper insights and lasting change. As we continue to explore and understand the full potential of this therapy, it remains a profound tool in the quest for healing and personal growth.

Reach out to us today to learn more about KAP and how we can support your growth!

Dr. Courtnay Meletta is an integrative psychotherapist licensed in the states of California and Rhode Island. She has enriched the mental health field for over a decade with her innovative approach combining holistic counseling, mind-body medicine, and somatic psychotherapy. She operates a successful practice in Los Angeles, mentors aspiring therapists, and engages in various therapeutic modalities including EMDR, Core Energetics, and psychedelic-assisted psychotherapy. Dr. Meletta is also an active contributor to the academic and corporate sectors, emphasizing leadership and personal growth through holistic practices. To read Dr. Courtnay Meletta’s bio, click here.

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